At least 56 civilians have been killed in fighting between the army and Rapid Support Forces (RSF) paramilitary group, an independent doctors group reports.
The Sudanese Doctors Union says dozens of soldiers have suffered casualties and at least 595 people have been wounded across the country.
Residents report heavy air strikes on paramilitary positions in and around Khartoum.
The RSF says it is in control of the presidential place, Khartoum airport and other vital facilities – claims the army has denied.
US Secretary of State Antony Blinken says he consulted with the foreign ministers of Saudi Arabia and the United Arab Emirates and the three countries urge all parties to “end hostilities without pre-condition”.
The fighting broke out after months of escalating tensions between the military’s commander, General Abdel Fattah al-Burhan, and the head of the RSF, General Mohamed Hamdan Dagalo, over the integration of the RSF into the army.